Perls’ Prussian Blue Staining

Perls’ Prussian Blue Staining

Procedure At A Glance Perls’ Prussian blue stain is used to histochemically detect and visualize ferric iron (Fe3+) deposits in cells and tissues. Preparation: Select and label positive control and test sample slides. Fix slides in absolute methanol for 10...
Megaloblastic Anemia

Megaloblastic Anemia

Key Takeaways Megaloblastic anemia is caused by defective DNA synthesis due to B12 deficiency or folate deficiency resulting in delayed red cell nucleus maturation in the bone marrow leading to macrocytic red cells (MCV > 95 fL in adults).  Signs and symptoms...
Iron Deficiency Anemia (IDA)

Iron Deficiency Anemia (IDA)

Key Takeaways Iron deficiency anemia is the most common nutritional deficiency worldwide. It develops when the body lacks the iron necessary to produce adequate hemoglobin, causing red blood cells to become smaller, paler, and less capable of carrying oxygen to...
Beta-Thalassemia

Beta-Thalassemia

Key Takeaways Beta-thalassemia is an inherited disorder caused by mutations in the HBB gene that reduce or stop production of the beta-globin chain of hemoglobin. The resulting imbalance between alpha and beta chains drives ineffective red cell production, ongoing red...
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