Primary Myelofibrosis (PMF)

Primary Myelofibrosis (PMF)

Key Takeaways Primary myelofibrosis is a rare chronic blood cancer originating in the bone marrow. Characterized by abnormal blood cell production, bone marrow fibrosis (scarring), and enlarged spleen. Pathogenesis ▾: Caused by clonal mutations in a...
Essential Thrombocythemia (ET)

Essential Thrombocythemia (ET)

Key Takeaways Essential thrombocythemia (ET) is a chronic blood cancer characterized by an abnormal increase in platelet production by the bone marrow, leading to an increased risk of blood clots (thrombosis) and bleeding complications. Pathogenesis ▾:Primarily...
Polycythemia Vera

Polycythemia Vera

Key Takeaways Polycythemia vera is a chronic blood disorder characterized by an increased production of red blood cells. It is caused by genetic mutations in the bone marrow particularly JAK2 mutations. Symptoms ▾: May include fatigue,...
Myeloproliferative Neoplasms (MPNs)

Myeloproliferative Neoplasms (MPNs)

Key Takeaways Myeloproliferative neoplasms (MPNs) are a group of chronic myeloid blood cancers characterized by overproduction of one or more types of blood cells in the bone marrow. Classifications ▾: Essential Thrombocythemia (ET): Increased platelet count...
Leukemia: An Overview

Leukemia: An Overview

Key Takeaways Leukemia is a cancer of the blood and bone marrow. It affects the cells responsible for fighting infection and carrying oxygen throughout the body. How does it occur? ▾: Normally, blood cells develop from stem cells in the bone marrow. In...
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