Factor V Leiden Thrombophilia

Factor V Leiden Thrombophilia

Key Takeaways Factor V Leiden thrombophilia is a genetic condition caused by a mutation in the F5 gene that results in a defective Factor V protein, making it resistant to inactivation by activated protein C (APC). Pathophysiology ▾: Because the mutated Factor...
Methemoglobinemia

Methemoglobinemia

Key Takeaways Methemoglobinemia is a blood disorder where the iron in hemoglobin is oxidized from its normal ferrous state (Fe2+) to the ferric state (Fe3+). This abnormal hemoglobin, called methemoglobin (MetHb), can’t carry oxygen. Pathophysiology ▾: It...
Eosinophilic Asthma

Eosinophilic Asthma

Key Takeaways Eosinophilic asthma is a severe, late-onset type of asthma characterized by a high number of eosinophils, which drives chronic airway inflammation that is often resistant to standard treatments and responds best to targeted biologic therapies. Symptoms...
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