Sickle Cell Anemia

Sickle Cell Anemia

Key Takeaways Sickle cell anemia is a hereditary chronic hemolytic anemia caused by the production of Hb S (a qualitative hemoglobin defect due to a β-globin gene codon 6 mutation [glutamic acid → valine]). Pathophysiology ▾: Sickle cell anemia is...
Components of Donated Blood Products

Components of Donated Blood Products

Key Takeaways Blood ProductStorageTransportExpiryIndicationsWhole bloodIn a blood bank refrigerator at 2℃ – 6℃Can be transported for the next 24h if maintained at 1℃ – 10℃ during transportation35 days in a closed system, 24 hr...
Acute Hemolytic Transfusion Reaction

Acute Hemolytic Transfusion Reaction

Key Takeaways Acute Hemolytic Transfusion Reaction (AHTR) is an acute hemolysis due to the administration of antigenically incompatible red cells.  Timing ▾: During transfusion or within 24 hours. Signs and Symptoms ▾: Fever and chills Back or flank...
Multiple Myeloma

Multiple Myeloma

Key Takeaways Multiple myeloma is a cancer of plasma cells, a type of white blood cell that produces antibodies. In this condition, abnormal plasma cells multiply uncontrollably and accumulate in the bone marrow. It is slightly more common in males than females and...
Hemophilia

Hemophilia

Key Takeaways Hemophilia, the most common severe, inherited bleeding disorder, represents a failure in the secondary hemostatic mechanism. It is an X-linked recessive disorder characterized by a deficiency or dysfunction of a specific plasma coagulation factor,...
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