Tumor Lysis Syndrome (TLS)

Tumor Lysis Syndrome (TLS)

Key Takeaways Tumor Lysis Syndrome or TLS is a life-threatening oncologic emergency caused by the rapid, massive lysis of malignant cells. This releases intracellular contents (potassium, phosphorus, and nucleic acids) into the systemic circulation, overwhelming...
Hemophagocytic Lymphohistiocytosis (HLH)

Hemophagocytic Lymphohistiocytosis (HLH)

Key Takeaways Hemophagocytic Lymphohistiocytosis  or HLH is a life-threatening “cytokine storm” where a broken “off-switch” in the immune system leads to unchecked, hyperactive T-cells and macrophages that attack the patient’s own...
Neutropenic Sepsis

Neutropenic Sepsis

Key Takeaways Neutropenic sepsis is a medical emergency defined by a fever (≥ 38.3°C (101°F)) and an ANC < 0.5 X 109/L. It requires a “door-to-needle” time of < 60 minutes for the first dose of broad-spectrum antibiotics....
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