Mast Cell

Mast Cell

Key Takeaways A mast cell is a long-lived immune cell that lives in tissues like the skin, gut, and lungs, where it acts as a first responder against pathogens and allergens by releasing histamine and other chemicals. Function ▾: Mast cells are best known for...
Systemic Mastocytosis

Systemic Mastocytosis

Key Takeaways Systemic Mastocytosis is a clonal myeloproliferative neoplasm characterized by the abnormal accumulation of neoplastic mast cells in extracutaneous organs, most commonly the bone marrow. Molecular Driver ▾: The KIT D816V somatic mutation is the...
Acute Intermittent Porphyria – AIP

Acute Intermittent Porphyria – AIP

Key Takeaways Acute Intermittent Porphyria or AIP is an autosomal dominant hepatic disorder causing acute neurovisceral crises without cutaneous symptoms. Etiology ▾: HMBS gene mutations triggered by porphyrinogenic drugs, progesterone, or caloric restriction....
Tumor Lysis Syndrome (TLS)

Tumor Lysis Syndrome (TLS)

Key Takeaways Tumor Lysis Syndrome or TLS is a life-threatening oncologic emergency caused by the rapid, massive lysis of malignant cells. This releases intracellular contents (potassium, phosphorus, and nucleic acids) into the systemic circulation, overwhelming...
Secret Link