Hereditary hemochromatosis, an inherited disorder, disrupts iron absorption leading to excessive iron buildup in organs like the liver, heart, and pancreas. Early diagnosis through blood tests is crucial to prevent potential complications like cirrhosis, heart failure, and diabetes. Treatment focuses on iron reduction through phlebotomy and may prevent severe health consequences.
Red Blood Cells
Sideroblastic Anemia
Sideroblastic anemia disrupts iron use in red blood cells. Caused by genetic mutations or factors like alcohol abuse, it’s diagnosed by analyzing bone marrow for ring sideroblasts, iron-laden structures.
Differential Diagnosis of Macrocytic Anemias
Macrocytosis, larger-than-normal red blood cells, can be a sign of vitamin B12 or folate deficiency, liver disease, or bone marrow issues. Early diagnosis is key for targeted treatment.
Hereditary Hemochromatosis
Hereditary hemochromatosis, an inherited disorder, disrupts iron absorption leading to excessive iron buildup in organs like the liver, heart, and pancreas. Early diagnosis through blood tests is crucial to prevent potential complications like cirrhosis, heart failure, and diabetes. Treatment focuses on iron reduction through phlebotomy and may prevent severe health consequences.
Sideroblastic Anemia
Sideroblastic anemia disrupts iron use in red blood cells. Caused by genetic mutations or factors like alcohol abuse, it’s diagnosed by analyzing bone marrow for ring sideroblasts, iron-laden structures.
Anemia of Chronic Disease (ACD)
ACD (anemia of chronic disease) occurs when inflammation disrupts iron use for red blood cells, causing anemia despite iron stores.
Differential Diagnosis of Hypochromic Anemia
Hypochromic anemia, marked by pale, small red blood cells, has various causes beyond iron deficiency. A proper diagnosis is crucial for effective treatment. Ruling out conditions like thalassemia or lead poisoning ensures targeted therapy.
Anemia of Chronic Disease (ACD)
ACD (anemia of chronic disease) occurs when inflammation disrupts iron use for red blood cells, causing anemia despite iron stores.
Red Blood Cell Inclusion Bodies
Red blood cell inclusions are hidden clues! These structures in RBCs signal underlying issues. Learn how they help diagnose anemia & other blood disorders.
Red Blood Cell (RBC) Morphology
Red blood cell (RBC) shapes and sizes offer clues to health! Normal RBCs are round and disc-shaped, but abnormal shapes like sickle or teardrop forms can indicate underlying conditions like anemia. Let’s explore what these variations mean!
Drug-Induced Immune Hemolytic Anemia (DIIHA)
Drug-induced immune hemolytic anemia (DIIHA) challenges diagnostic workup due to diverse mechanisms (hapten model most common). Consider DIIHA in hemolytic anemia with recent medication initiation & positive DAT.
Autoimmune Hemolytic Anemia (AIHA)
AIHA: When your own immune system attacks healthy red blood cells, causing anemia. Treatment aims to suppress this immune response
