White Blood Cells (WBCs)

White Blood Cells (WBCs)

Key Takeaways WBCs, also called leukocytes, are the body’s defense cells. They protect against bacteria, viruses, fungi, parasites, and abnormal cells like cancer cells. Types of White Blood Cells ▾: There are five main types of WBCs in circulation:...
Primary Myelofibrosis (PMF)

Primary Myelofibrosis (PMF)

Key Takeaways Primary myelofibrosis is a rare, chronic blood cancer in which the bone marrow becomes scarred (fibrosed), blood cell production goes haywire, and the spleen typically enlarges. It is one of three classic Philadelphia-negative myeloproliferative...
Essential Thrombocythemia (ET)

Essential Thrombocythemia (ET)

Key Takeaways Essential thrombocythemia is a chronic blood cancer (specifically a myeloproliferative neoplasm) in which the bone marrow produces too many platelets, raising the risk of both clots and bleeding [1]. Pathogenesis ▾:Primarily driven by mutations in...
Polycythemia Vera

Polycythemia Vera

Key Takeaways Polycythemia vera is a chronic blood cancer of the bone marrow that produces too many red blood cells, and often too many platelets and white cells as well. Roughly 95–97% of cases are driven by a mutation in the JAK2 gene [1]. Symptoms ▾:...
Myeloproliferative Neoplasms (MPNs)

Myeloproliferative Neoplasms (MPNs)

Key Takeaways A myeloproliferative neoplasm is a chronic blood cancer in which bone marrow makes too many mature blood cells — red cells, white cells, platelets, or a combination. The three classical BCR::ABL1-negative MPNs are essential thrombocythemia (ET),...
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