by MH Team | Oct 16, 2023 | Platelet Disorders
TL;DR Hemorrhagic disease of the newborn is a vitamin K deficiency bleeding disorder that occurs in newborns caused by lack of vitamin K. Causes Liver cell immaturity Lack of gut bacterial synthesis Low quantities in breastmilk Laboratory diagnosis ▾ Abnormal PT...
by MH Team | Oct 16, 2023 | Platelet Disorders
TL;DR Von Willebrand disease or disorder is an inherited coagulation disorder caused by mutations in the von Willebrand factor (vWF). vWF is a factor VIII carrier protein and mediates platelet adhesion to endothelium Pathogenesis ▾ Quantitative deficiency Type 1:...
by MH Team | Oct 15, 2023 | Transfusion Medicine
TL;DR Hemolytic disease of the fetus and newborn (HDFN) also known as erythroblastosis fetalis is an allo-immune hemolytic anemia in the fetus or newborn. This is due to a fetal-maternal incompatibility for one of the red cell blood group systems i.e. Rh blood group...
by MH Team | Oct 9, 2023 | Lab Protocols, White Blood Cells
Procedure-At-A-Glance The myeloperoxidase reaction (MPO) stain works by utilizing the peroxidase in leukocyte granules to oxidize a chromogen (like benzidine) in the presence of hydrogen peroxide (H2O2), forming an insoluble, colored reaction product (colorless to...
by MH Team | Oct 9, 2023 | Lab Protocols, White Blood Cells
Procedure-At-A-Glance The May-Grünwald Giemsa or MGG stain is a type of Romanowsky stain, similar to the Leishman stain, and works on the same principle. It is used for morphology assessment of blood cells, bone marrow aspirates, and cells in body fluids, which is...
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