by MH Team | Jan 18, 2024 | Commentaries, rbc
Introduction SCD arises from a single nucleotide mutation in the beta-globin gene (HBB) on chromosome 11. This mutation leads to the substitution of valine for glutamic acid at the sixth amino acid position of the beta-globin chain in the hemoglobin molecule. This...
by MH Team | Jan 16, 2024 | Lab Protocols, Red Blood Cells
Procedure At a Glance The Dithionite Solubility Test (Sickle Cell Disease Test) is a screening method used to detect the presence of abnormal Hemoglobin S (HbS), indicative of Sickle Cell Disease or Sickle Cell Trait. Ensure a freshly prepared dithionite solution is...
by MH Team | Jan 11, 2024 | Platelet Disorders
TL;DR Key Function of Fibrinolysis: Dissolves fibrin clots after wound healing, restoring blood flow and preventing unwanted thrombus formation. Essential Players ▾ Plasminogen: The inactive precursor protein, waiting to be activated. Plasmin: The active enzyme...
by MH Team | Jan 8, 2024 | Platelet Disorders
TL;DR The coagulation cascade is a complex series of biochemical reactions that occur in the blood when a vessel is injured. It’s a tightly regulated process that involves numerous proteins, called coagulation factors, working together to form a blood clot and...
by MH Team | Jan 5, 2024 | Lab Protocols, Transfusion Medicine
Procedure At a Glance Prepare Patient Sample: Centrifuge patient serum to obtain plasma/serum. Prepare Red Blood Cells (RBCs): Make a 2-5% suspension of donor or reagent RBCs in normal saline. Combine Serum & RBCs: Add patient serum to the prepared RBC suspension....
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