Megaloblastic Anemia

Megaloblastic Anemia

TL;DR Megaloblastic anemia is caused by defective DNA synthesis due to B12 deficiency or folate deficiency resulting in delayed red cell nucleus maturation in the bone marrow leading to macrocytic red cells (MCV > 95 fL in adults).  Signs and symptoms ▾:...
Iron Deficiency Anemia (IDA)

Iron Deficiency Anemia (IDA)

TL;DR Iron deficiency anemia or IDA is caused by defective heme or hemoglobin synthesis due to the lack of iron.   Iron deficiency symptoms & signs ▾: GeneralSpecificFatigueWeaknessPallorHeadachesDizziness or lightheadednessShortness of breathChest...
Beta Thalassemia

Beta Thalassemia

TL;DR Beta thalassemia is a hereditary hemoglobin disorder due to reduced or absence of beta-globin chain production leading to ineffective erythropoiesis and anemia. It is predominantly an autosomal recessive gene disorder. Classifications CharacteristicBeta...
Hereditary Spherocytosis

Hereditary Spherocytosis

TL;DR Hereditary spherocytosis is an inherited hemolytic anemia due to a defect in a red cell membrane protein. It has mainly an autosomal dominant inheritance pattern. Signs and symptoms ▾: Mild to moderate anemia Intermittent jaundice precipitated by pregnancy,...