Hodgkin Lymphoma


Lymphomas are a group of diseases caused by malignant lymphocytes that accumulate in lymph nodes and cause lymphadenopathy.

Signs & Symptoms

Painless, non-tender, asymmetrical, firm, discrete and rubbery enlargement of superficial lymph nodes. Splenomegaly.

Risk Factors

“Bimodal“-majority in young adults. Rare in children. 2:1 (> male).

Peripheral blood characteristics

Normochromic, normocytic anemia. Neutrophilia and eosinophilia are frequent. Platelet count is normal or increased during early stages of the disease and decreased in the later stages.

Important investigations & related results

Reed-Sternberg cells are seen. CD20+, CD15+ and B cell antigen is negative. ESR and CRP usually raised. Serum LDH is increased initially.


Ann Arbor (Stage I – IV) and A or B.

Treatment & management

Radiotherapy or chemotherapy or both. Depends on stage and A or B.

Histological findings in lymph node biopsy with Reed-Sternberg cells.

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