by MH Team | Dec 17, 2023 | Platelet Disorders
Introduction Platelets are tiny cellular fragments that play a crucial role in the process of blood clotting, known as hemostasis. They are produced in the bone marrow from larger cells called megakaryocytes. When a vessel wall is breached, platelets are the first...
by MH Team | Dec 14, 2023 | White Blood Cells
TL;DR Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic malignancies due to impaired maturation of myeloid progenitors leading to cytopenias and dysplasia of myeloid-lineage cells. Peak incidence > 70 years old. Signs and...
by MH Team | Dec 11, 2023 | Lab Protocols, Red Blood Cells
Introduction Hemolysate, a suspension of lysed red blood cells, plays a crucial role in both Hb electrophoresis and alkaline denaturation tests. These tests rely on the biochemical properties of hemoglobin to differentiate between different types of hemoglobin and...
by MH Team | Dec 11, 2023 | Lab Protocols, Platelet Disorders
Introduction The activated partial thromboplastin time (APTT) is a coagulation test that measures the intrinsic pathway of blood clotting. While the APTT itself is a valuable diagnostic tool, it can be further enhanced through the use of manual mixing studies. Mixing...
by MH Team | Dec 5, 2023 | White Blood Cells
TL;DR Acute myeloid leukemia (AML) is an aggressive neoplasm of the myeloid lineage caused by acquired somatic defects due to either environmental influences e.g. chemicals, drugs, radiation or infections e.g.bacteria, protozoa in early hematopoietic blasts that...
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