by MH Team | Oct 16, 2023 | Platelet Disorders
TL;DR Hemorrhagic disease of the newborn is a vitamin K deficiency bleeding disorder that occurs in newborns caused by lack of vitamin K. Causes Liver cell immaturity Lack of gut bacterial synthesis Low quantities in breastmilk Laboratory diagnosis ▾ Abnormal PT and...
by MH Team | Oct 16, 2023 | Platelet Disorders
TL;DR Von Willebrand disease or disorder is an inherited coagulation disorder caused by mutations in the von Willebrand factor (vWF). vWF is a factor VIII carrier protein and mediates platelet adhesion to endothelium Pathogenesis ▾ Quantitative deficiency Type 1:...
by MH Team | Oct 15, 2023 | Transfusion Medicine
TL;DR Hemolytic disease of the newborn (HDN) also known as erythroblastosis fetalis is an allo-immune hemolytic anemia in the fetus or newborn. This is due to a fetal-maternal incompatibility for one of the red cell blood group systems i.e. Rh group causing maternal...
by MH Team | Oct 9, 2023 | Lab Protocols, White Blood Cells
Introduction Myeloperoxidase is a lysosomal enzyme, located in the azurophilic granules of the neutrophils and its precursors, eosinophils and monocytes. This MPO stain is mainly used to differentiate acute myeloid leukaemia from acute lymphoblastic leukaemia. MPO...
by MH Team | Oct 9, 2023 | Lab Protocols, White Blood Cells
Introduction Similar to the Leishman stain, MGG is part of the Romanowsky stains and adopts the same principle. MGG stain consists of May-Grünwald stain and Giemsa stain. MGG stain is used for morphology assessment of bone marrow aspirates especially in diseases like...
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