TL;DR Beta-thalassemia is a hereditary hemoglobin disorder due to reduced or absence of beta-globin chain production leading to ineffective erythropoiesis and anemia. It is predominantly an autosomal recessive gene disorder. Epidemiology Approximately 1.5% of the...
TL;DR Hereditary spherocytosis is an inherited hemolytic anemia due to a defect in a red cell membrane protein. It has mainly an autosomal dominant inheritance pattern. Signs and symptoms ▾ Mild to moderate anemia Intermittent jaundice precipitated by pregnancy,...
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