by MyH Editorial Team | Aug 15, 2025 | Hemostasis Disorders
Key Takeaways Factor V Leiden thrombophilia is a genetic condition caused by a mutation in the F5 gene that results in a defective Factor V protein, making it resistant to inactivation by activated protein C (APC). Pathophysiology ▾: Because the mutated Factor...
by MyH Editorial Team | Aug 13, 2025 | Red Blood Cells
Key Takeaways Methemoglobinemia is a blood disorder where the iron in hemoglobin is oxidized from its normal ferrous state (Fe2+) to the ferric state (Fe3+). This abnormal hemoglobin, called methemoglobin (MetHb), can’t carry oxygen. Pathophysiology ▾: It...
by MyH Editorial Team | Aug 10, 2025 | White Blood Cells
Key Takeaways Eosinophilic asthma is a severe, late-onset type of asthma characterized by a high number of eosinophils, which drives chronic airway inflammation that is often resistant to standard treatments and responds best to targeted biologic therapies. Symptoms...
by MyH Editorial Team | Aug 2, 2025 | White Blood Cells
Key Takeaways Hypereosinophilic syndrome (HES) is a rare group of disorders characterized by persistently high blood eosinophils (≥1,500/μL), leading to inflammation and organ damage. Pathophysiology ▾: Caused by eosinophil overproduction and toxic...
by MyH Editorial Team | Jul 29, 2025 | White Blood Cells
Key Takeaways A leukemoid reaction is a benign, reactive process characterized by a marked increase in white blood cells (leukocytosis, often >50,000/µL) with immature myeloid forms (left shift), but it is not a malignancy. Physiological Basis ▾: It...
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