Chronic Lymphocytic Leukemia (CLL)

Chronic Lymphocytic Leukemia (CLL)

TL;DR Chronic lymphocytic leukemia (CLL) is a slow progressing cancer due to overgrowth and accumulation of small incompetent mature-looking B-lymphocytes in the blood, bone marrow and lymphoid tissues. Small lymphocytic leukemia is a different clinical manifestation...
Acute Leukemia: An Overview

Acute Leukemia: An Overview

Introduction Acute leukemia, a devastating form of blood cancer, arises from the uncontrolled growth and proliferation of immature blood cells, known as blasts. These abnormal cells crowd out the healthy blood cells, disrupting the body’s ability to produce...
Perls’ Prussian Blue Staining

Perls’ Prussian Blue Staining

Introduction Perls’ stain, also known as Prussian blue stain, is a widely used histochemical method that specifically identifies ferric iron (Fe3+) deposits in tissue and cell samples. It works by causing the formation of an insoluble bright blue pigment,...
Megaloblastic Anemia

Megaloblastic Anemia

TL;DR Megaloblastic anemia is caused by defective DNA synthesis due to B12 deficiency or folic acid deficiency resulting in delayed red cell nucleus maturation in the bone marrow leading to macrocytic red cells (MCV > 95 fL in adults).  Signs and symptoms ▾...