Chronic Lymphocytic Leukemia (CLL)

Chronic Lymphocytic Leukemia (CLL)

TL;DR Chronic lymphocytic leukemia (CLL) is a slow progressing cancer due to overgrowth and accumulation of small incompetent mature-looking B-lymphocytes in the blood, bone marrow and lymphoid tissues. Small lymphocytic leukemia is a different clinical manifestation...
Acute Leukemia: An Overview

Acute Leukemia: An Overview

Introduction Acute leukemia, a devastating form of blood cancer, arises from the uncontrolled growth and proliferation of immature blood cells, known as blasts. These abnormal cells crowd out the healthy blood cells, disrupting the body’s ability to produce...
Perls’ Prussian Blue Staining

Perls’ Prussian Blue Staining

Procedure At A Glance Perls’ Prussian blue stain is used to histochemically detect and visualize ferric iron (Fe3+) deposits in cells and tissues. Preparation: Select and label positive control and test sample slides. Fix slides in absolute methanol for 10...
Megaloblastic Anemia

Megaloblastic Anemia

TL;DR Megaloblastic anemia is caused by defective DNA synthesis due to B12 deficiency or folic acid deficiency resulting in delayed red cell nucleus maturation in the bone marrow leading to macrocytic red cells (MCV > 95 fL in adults).  Signs and symptoms ▾...