Hodgkin Lymphoma & Reed-Sternberg

Hodgkin Lymphoma & Reed-Sternberg

TL;DR Hodgkin Lymphoma is a heterogeneous group of disorders caused by malignant lymphocytes that accumulate in lymph nodes presenting as lymphadenopathy. Hodgkin lymphoma is differentiated from non-Hodgkin lymphoma by presence of Reed-Sternberg (RS) cells and a...
Chronic Myeloid Leukemia (CML)

Chronic Myeloid Leukemia (CML)

TL;DR Chronic myeloid leukemia (CML) is a slower progressing clonal disorder of the hematopoietic stem cells where untreated patients progress to blast crisis stage after 3 – 5 years. It has a peak incidence at 40 – 60 years old. Signs and symptoms ▾...
Chronic Lymphocytic Leukemia (CLL)

Chronic Lymphocytic Leukemia (CLL)

TL;DR Chronic lymphocytic leukemia (CLL) is a slow progressing cancer due to overgrowth and accumulation of small incompetent mature-looking B-lymphocytes in the blood, bone marrow and lymphoid tissues. Small lymphocytic leukemia is a different clinical manifestation...
Acute Leukemia: An Overview

Acute Leukemia: An Overview

Introduction Acute leukemia, a devastating form of blood cancer, arises from the uncontrolled growth and proliferation of immature blood cells, known as blasts. These abnormal cells crowd out the healthy blood cells, disrupting the body’s ability to produce...
Perls’ Prussian Blue Staining

Perls’ Prussian Blue Staining

Introduction Prussian blue (Perls’) reaction is a method for staining non-heme iron in normoblasts (siderocytes), macrophages (hemosiderin), and other cells containing particulate iron. The granules are formed of a water-insoluble complex of ferric iron, lipid,...