TL;DR Hemophilia is an inherited coagulation disorder caused by mutations on factor VIII gene leading to deficiency in plasma factor VIII for hemophilia A while mutations on factor IX gene for hemophilia B causes decreased factor IX. It is an X-linked recessive...
TL;DR Hemorrhagic disease of the newborn is a vitamin K deficiency bleeding disorder that occurs in newborns caused by lack of vitamin K. Causes Liver cell immaturity Lack of gut bacterial synthesis Low quantities in breastmilk Laboratory diagnosis ▾ Abnormal PT and...
TL;DR Von Willebrand disease or disorder is an inherited coagulation disorder caused by mutations in the von Willebrand factor (vWF). vWF is a factor VIII carrier protein and mediates platelet adhesion to endothelium Pathogenesis ▾ Quantitative deficiency Type 1:...
TL;DR Hemolytic disease of the newborn (HDN) also known as erythroblastosis fetalis is an allo-immune hemolytic anemia in the fetus or newborn. This is due to a fetal-maternal incompatibility for one of the red cell blood group systems i.e. Rh group causing maternal...
Introduction Myeloperoxidase is a lysosomal enzyme, located in the azurophilic granules of the neutrophils and its precursors, eosinophils and monocytes. This MPO stain is mainly used to differentiate acute myeloid leukaemia from acute lymphoblastic leukaemia. MPO...
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