by MH Team | Nov 7, 2025 | White Blood Cells
Key Takeaways The plasma cell is the terminal, non-proliferating B-lymphocyte dedicated to antibody secretion. Plasma cells originate from B-cells via the Germinal Center (GC) reaction in lymphoid organs. Morphology ▾: Plasma cells has an eccentric nucleus with...
by MH Team | Nov 3, 2025 | White Blood Cells
Key Takeaways Monoclonal Gammopathy of Undetermined Significance (MGUS) is an asymptomatic premalignant plasma cell or lymphoplasmacytic disorder. Classification ▾: Divided into Non-IgM MGUS (most common, precursor to Multiple Myeloma, MM), IgM MGUS (precursor...
by MH Team | Nov 1, 2025 | White Blood Cells
Key Takeaways Smoldering Multiple Myeloma (SMM) is an intermediate, asymptomatic stage between Monoclonal Gammopathy of Undetermined Significance (MGUS) (low-risk) and Active Multiple Myeloma (MM) (symptomatic, requiring treatment). Pathophysiology ▾:...
by MH Team | Oct 25, 2025 | Platelet Disorders
Key Takeaways Hemophilia A (Classic Hemophilia) is an inherited bleeding disorder defined by a quantitative or qualitative deficiency of Factor VIII (FVIII). Etiology & Inheritance: Hemophilia A is an X-linked recessive disorder caused by mutations in the F8 gene...
by MH Team | Oct 9, 2025 | Transfusion Medicine
Key Takeaways A transfusion reaction is defined as any adverse event or unintended response in a patient that is associated with the administration of whole blood or one of its components. Reaction TypePrimary CausePathophysiology/MechanismClassic SymptomsInitial...
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