Delayed Hemolytic Transfusion Reaction

Delayed Hemolytic Transfusion Reaction

Key Takeaways A Delayed Hemolytic Transfusion Reaction (DHTR) is an immune-mediated adverse event that occurs as a consequence of a blood transfusion. Its defining characteristic is the delayed onset, with signs and symptoms typically appearing 3 to 30 days...
Microangiopathic Hemolytic Anemia (MAHA)

Microangiopathic Hemolytic Anemia (MAHA)

Key Takeaways Microangiopathic hemolytic anemia or MAHA is a syndrome defined by a triad of microangiopathic damage, hemolytic anemia, and thrombocytopenia, all resulting from the physical fragmentation of red blood cells in small blood vessels. Pathophysiology...
Pancytopenia

Pancytopenia

Key Takeaways Pancytopenia is the reduction of all three major blood cell lines: red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia). It is a clinical finding, not a disease itself, indicating an underlying issue. Causes ▾...
Shwachman-Diamond Syndrome (SDS)

Shwachman-Diamond Syndrome (SDS)

Key Takeaways Shwachman-Diamond syndrome or SDS is a rare, autosomal recessive genetic disorder caused by a mutation in the SBDS gene on chromosome 7. Cause ▾: Shwachman-Diamond Syndrome (SDS) is a rare, inherited genetic disorder. It is an autosomal recessive...
Bone Marrow Failure

Bone Marrow Failure

Key Takeaways Bone marrow failure is the inability of the bone marrow to produce enough mature blood cells, leading to low counts (pancytopenia). Causes ▾: The causes are broadly divided into acquired and inherited. Acquired causes include immune-mediated...
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