by MyH Editorial Team | Nov 14, 2023 | Lab Protocols, Red Blood Cells
Procedure-at-a-Glance A PCR protocol for the beta-globin (HBB) gene amplifies the entire 1.6 kb gene so it can be sequenced and screened for mutations that cause beta thalassemia. Thaw reagents and UV-sterilize the workstation. Make a master mix by combining...
by MyH Editorial Team | Nov 13, 2023 | Transfusion Medicine
Key Takeaways The ABO blood group is the most clinically important blood group system in transfusion and organ transplantation. A mismatch can trigger acute intravascular hemolysis, kidney failure, and death within minutes. Three antigens define the system: A, B, and...
by MyH Editorial Team | Nov 9, 2023 | Lab Protocols, White Blood Cells
Procedure-at-a-Glance The leukocyte alkaline phosphatase (LAP) stain, also called the neutrophil alkaline phosphatase (NAP) stain, is a cytochemical test that measures the enzyme alkaline phosphatase inside mature neutrophils. Fix fresh smears in Cold...
by MyH Editorial Team | Nov 9, 2023 | Red Blood Cells
Key Takeaways Aplastic anemia is a bone marrow failure disorder in which the marrow stops producing enough red blood cells, white blood cells, and platelets, leading to pancytopenia. Signs and symptoms ▾: Lethargy, pallor (anemia), infections especially mouth...
by MyH Editorial Team | Nov 3, 2023 | Hemostasis Disorders
Key Takeaways Thrombotic thrombocytopenic purpura is a rare, life-threatening blood disorder in which tiny clots form in small blood vessels throughout the body, driven by a missing or blocked enzyme called ADAMTS13 [1,4]. Signs and symptoms ▾: The classic...
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