Perls’ Prussian Blue Staining

Perls’ Prussian Blue Staining

Introduction Perls’ stain, also known as Prussian blue stain, is a widely used histochemical method that specifically identifies ferric iron (Fe3+) deposits in tissue and cell samples. It works by causing the formation of an insoluble bright blue pigment,...
Megaloblastic Anemia

Megaloblastic Anemia

TL;DR Megaloblastic anemia is caused by defective DNA synthesis due to B12 deficiency or folic acid deficiency resulting in delayed red cell nucleus maturation in the bone marrow leading to macrocytic red cells (MCV > 95 fL in adults).  Signs and symptoms ▾...
Iron Deficiency Anemia (IDA)

Iron Deficiency Anemia (IDA)

TL;DR Iron deficiency anemia is caused by defective heme or hemoglobin synthesis due to the lack of iron.   Iron deficiency symptoms & signs ▾ GeneralSpecificFatigueWeaknessPallorHeadachesDizziness or lightheadednessShortness of breathChest...
Beta Thalassemia

Beta Thalassemia

TL;DR Beta thalassemia is a hereditary hemoglobin disorder due to reduced or absence of beta-globin chain production leading to ineffective erythropoiesis and anemia. It is predominantly an autosomal recessive gene disorder. Classifications CharacteristicBeta...