by MH Team | Oct 9, 2023 | Lab Protocols, Red Blood Cells
Introduction Prussian blue (Perls’) reaction is a method for staining non-heme iron in normoblasts (siderocytes), macrophages (hemosiderin), and other cells containing particulate iron. The granules are formed of a water-insoluble complex of ferric iron, lipid,...
by MH Team | Oct 9, 2023 | Lab Protocols, Red Blood Cells
Introduction The Leishman stain, characterized by its contrasting hues of blue, pink, and purple, offers a deeper understanding of cellular morphology and differentiation. The nuclei of cells stain a crisp blue, while the cytoplasm takes on vibrant pink or purple hues...
by MH Team | Oct 9, 2023 | Red Blood Cells
TL;DR Megaloblastic anemia is caused by defective DNA synthesis due to B12 deficiency or folic acid deficiency resulting in delayed red cell nucleus maturation in the bone marrow leading to macrocytic red cells (MCV > 95 fL in adults). Signs and symptoms ▾...
by MH Team | Oct 9, 2023 | Red Blood Cells
TL;DR Iron deficiency anemia is caused by defective heme or hemoglobin synthesis due to the lack of iron. Iron deficiency symptoms & signs ▾ GeneralSpecificFatigueWeaknessPallorHeadachesDizziness or lightheadednessShortness of breathChest...
by MH Team | Oct 9, 2023 | Red Blood Cells
TL;DR Beta thalassemia is a hereditary hemoglobin disorder due to reduced or absence of beta-globin chain production leading to ineffective erythropoiesis and anemia. It is predominantly an autosomal recessive gene disorder. Epidemiology Approximately 1.5% of the...
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