Introduction Acute leukemia, a devastating form of blood cancer, arises from the uncontrolled growth and proliferation of immature blood cells, known as blasts. These abnormal cells crowd out the healthy blood cells, disrupting the body’s ability to produce...
Introduction Prussian blue (Perls’) reaction is a method for staining non-heme iron in normoblasts (siderocytes), macrophages (hemosiderin), and other cells containing particulate iron. The granules are formed of a water-insoluble complex of ferric iron, lipid,...
Introduction The Leishman stain, characterized by its contrasting hues of blue, pink, and purple, offers a deeper understanding of cellular morphology and differentiation. The nuclei of cells stain a crisp blue, while the cytoplasm takes on vibrant pink or purple hues...
TL;DR Megaloblastic anemia is caused by defective DNA synthesis due to B12 deficiency or folic acid deficiency resulting in delayed red cell nucleus maturation in the bone marrow leading to macrocytic red cells (MCV > 95 fL in adults). Signs and symptoms ▾...
TL;DR Iron deficiency anemia is caused by defective heme or hemoglobin synthesis due to the lack of iron. Iron deficiency symptoms & signs ▾ GeneralSpecificFatigueWeaknessPallorHeadachesDizziness or lightheadednessShortness of breathChest...
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