by MH Team | Oct 18, 2023 | Transfusion Medicine
TL;DR Definition ▾ Acute hemolytic transfusion reaction is an acute hemolysis due to the administration of antigenically incompatible red cells. Timing ▾ During transfusion or within 24 hours. Signs and Symptoms ▾ Fever: Often the first sign, occurring within minutes...
by MH Team | Oct 17, 2023 | White Blood Cells
TL;DR Multiple myeloma is a cancer of plasma cells, a type of white blood cell that produces antibodies. In this condition, abnormal plasma cells multiply uncontrollably and accumulate in the bone marrow. It is slightly more common in males than females and most...
by MH Team | Oct 17, 2023 | Platelet Disorders
TL;DR Hemophilia is an inherited coagulation disorder caused by mutations on factor VIII gene leading to deficiency in plasma factor VIII for hemophilia A while mutations on factor IX gene for hemophilia B causes decreased factor IX. It is an X-linked recessive...
by MH Team | Oct 16, 2023 | Platelet Disorders
TL;DR Hemorrhagic disease of the newborn is a vitamin K deficiency bleeding disorder that occurs in newborns caused by lack of vitamin K. Causes Liver cell immaturity Lack of gut bacterial synthesis Low quantities in breastmilk Laboratory diagnosis ▾ Abnormal PT and...
by MH Team | Oct 16, 2023 | Platelet Disorders
TL;DR Von Willebrand disease or disorder is an inherited coagulation disorder caused by mutations in the von Willebrand factor (vWF). vWF is a factor VIII carrier protein and mediates platelet adhesion to endothelium Pathogenesis ▾ Quantitative deficiency Type 1:...
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