Acute Hemolytic Transfusion Reaction (ATHR)

Acute Hemolytic Transfusion Reaction (ATHR)

TL;DR Definition ▾ Acute hemolytic transfusion reaction is an acute hemolysis due to the administration of antigenically incompatible red cells.  Timing ▾ During transfusion or within 24 hours. Signs and Symptoms ▾ Fever: Often the first sign, occurring within minutes...
Multiple Myeloma

Multiple Myeloma

TL;DR Multiple myeloma is a cancer of plasma cells, a type of white blood cell that produces antibodies. In this condition, abnormal plasma cells multiply uncontrollably and accumulate in the bone marrow. It is slightly more common in males than females and most...
Hemophilia

Hemophilia

TL;DR Hemophilia is an inherited coagulation disorder caused by mutations on factor VIII gene leading to deficiency in plasma factor VIII for hemophilia A while mutations on factor IX gene for hemophilia B causes decreased factor IX. It is an X-linked recessive...
von Willebrand Disorder (vWD)

von Willebrand Disorder (vWD)

TL;DR Von Willebrand disease or disorder is an inherited coagulation disorder caused by mutations in the von Willebrand factor (vWF). vWF is a factor VIII carrier protein and mediates platelet adhesion to endothelium Pathogenesis ▾ Quantitative deficiency Type 1:...