by MH Team | Mar 19, 2025 | Platelet Disorders, Tests
TL;DR Elevated lipoprotein(a) [Lp(a)] is an independent risk factor for heart disease and stroke, particularly due to increased blood clot formation. Genetic Predominance ▾: Lp(a) levels are primarily determined by genetics. Cardiovascular Risk ▾: Elevated Lp(a) is an...
by MH Team | Mar 17, 2025 | White Blood Cells
TL;DR Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated esophageal disease. It’s characterized by eosinophil-predominant inflammation. Epidemiology ▾: Increasing prevalence, particularly in children and young adults. Male predominance. Linked...
by MH Team | Mar 14, 2025 | White Blood Cells
TL;DR AL amyloidosis is a systemic disease caused by a clonal plasma cell disorder, leading to the production and deposition of abnormal light-chain amyloid fibrils in organs and tissues. Pathophysiology ▾: Abnormal plasma cells overproduce light chains that misfold,...
by MH Team | Mar 12, 2025 | White Blood Cells
TL;DR Sjögren’s syndrome is a systemic autoimmune disease primarily targeting exocrine glands (dry eyes, mouth). Pathophysiology ▾: Lymphocytic infiltration, autoantibody production (anti-Ro/SSA, anti-La/SSB), genetic predisposition, and potential environmental...
by MH Team | Mar 10, 2025 | White Blood Cells
TL;DR Waldenström macroglobulinemia (WM) is a rare, slow-growing B-cell lymphoma characterized by the overproduction of IgM monoclonal immunoglobulin by lymphoplasmacytic lymphoma (LPL) cells. Pathophysiology ▾: Primarily driven by the MYD88 L265P mutation, leading to...
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