Sjögren’s Syndrome

Sjögren’s Syndrome

Key Takeaways Sjögren’s syndrome is a systemic autoimmune disease primarily targeting exocrine glands (dry eyes, mouth). Pathophysiology ▾: Lymphocytic infiltration, autoantibody production (anti-Ro/SSA, anti-La/SSB), genetic predisposition, and...
Waldenström Macroglobulinemia

Waldenström Macroglobulinemia

Key Takeaways Waldenström macroglobulinemia (WM) is a rare, slow-growing B-cell lymphoma characterized by the overproduction of IgM monoclonal immunoglobulin by lymphoplasmacytic lymphoma (LPL) cells. Pathophysiology ▾: Primarily driven by the MYD88 L265P...
Pulmonary Embolism (PE)

Pulmonary Embolism (PE)

Key Takeaways Pulmonary embolism (PE) is a blockage in lung arteries, usually from a DVT. Risk factors involve Virchow’s triad ▾: hypercoagulability, venous stasis, endothelial injury. Pathophysiology ▾: Increased pulmonary resistance, right heart...
Peripheral Artery Disease (PAD)

Peripheral Artery Disease (PAD)

Key Takeaways Peripheral artery disease (PAD) is the narrowing of arteries outside the heart, primarily in the legs, due to atherosclerosis. Cause ▾: Atherosclerosis (plaque buildup) is the main cause. Symptoms ▾: Intermittent claudication (leg pain with...
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