by MyH Editorial Team | Apr 6, 2025 | White Blood Cells
This blog post provides an overview of Chronic Myeloid Leukemia (CML) and its treatment strategies based on the most recent guideline (2025) from the National Comprehensive Cancer Network (NCCN). Key Takeaways Tyrosine kinase inhibitors (TKIs) are the primary...
by MyH Editorial Team | Apr 4, 2025 | Red Blood Cells
Key Takeaways Hemoglobinuria is the presence of free hemoglobin in urine, distinct from hematuria (whole RBCs). It occurs when intravascular hemolysis overwhelms the body’s hemoglobin-handling capacity (haptoglobin, hemopexin). Causes ▾: Transfusion...
by MyH Editorial Team | Apr 2, 2025 | Red Blood Cells
Key Takeaways Hematuria is the presence of blood in the urine, either visible (gross) or microscopic. Causes ▾: Ranges from benign (UTIs, stones, exercise) to serious (glomerulonephritis, cancer). Symptoms ▾: Can be asymptomatic or include pain,...
by MyH Editorial Team | Mar 31, 2025 | Red Blood Cells
Key Takeaways Paroxysmal cold hemoglobinuria is a rare autoimmune hemolytic anemia caused by the Donath-Landsteiner (DL) antibody. Pathophysiology ▾: DL antibody (IgG) binds to red blood cells (RBCs) in cold temperatures. Upon warming, complement activation...
by MyH Editorial Team | Mar 28, 2025 | Red Blood Cells
Key Takeaways Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired clonal hematopoietic stem cell disorder characterized by complement-mediated hemolysis. Pathophysiology ▾: PIGA gene mutation leading to deficiency of GPI-anchored proteins (CD55,...
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