TL;DR Primary myelofibrosis is a rare chronic blood cancer originating in the bone marrow. Characterized by abnormal blood cell production, bone marrow fibrosis (scarring), and enlarged spleen. Pathogenesis ▾ Caused by clonal mutations in a hematopoietic stem cell,...
TL;DR Essential thrombocythemia (ET) is a chronic blood cancer characterized by an abnormal increase in platelet production by the bone marrow, leading to an increased risk of blood clots (thrombosis) and bleeding complications. Pathogenesis ▾ Primarily driven by...
TL;DR Polycythemia vera (PV) is a chronic blood disorder characterized by an increased production of red blood cells. It is caused by genetic mutations in the bone marrow particularly JAK2 mutations. Polycythemia Vera (PV) Symptoms ▾ May...
TL;DR Myeloproliferative neoplasms (MPNs) are a group of chronic blood cancers characterized by overproduction of one or more types of blood cells in the bone marrow. Classifications ▾ Essential Thrombocythemia (ET): Increased platelet count Polycythemia Vera (PV):...
TL;DR Leukemia is a cancer of the blood and bone marrow. It affects the cells responsible for fighting infection and carrying oxygen throughout the body. How does it occur? ▾ Normally, blood cells develop from stem cells in the bone marrow. In leukemia, the...
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