Systemic Approach to Anemia

Systemic Approach to Anemia

TL;DR Detailed Clinical History ▾ Explore presenting illness (symptoms, onset, duration, severity). Investigate menstrual history (regularity, bleeding amount) for women. Review past medical, surgical, and drug history. Assess social history (occupation, travel,...
Hereditary Hemochromatosis

Hereditary Hemochromatosis

TL;DR Hereditary hemochromatosis is a genetic disorder affecting iron metabolism, leading to excessive iron absorption from the diet. It is the most common genetic disease in populations of Northern European descent. Causes ▾ Primarily caused by mutations in the HFE...
Sideroblastic Anemia

Sideroblastic Anemia

TL;DR Sideroblastic anemia is a type of anemia characterized by abnormal iron metabolism within red blood cell precursors. Refractory anemia is defined by the presence of many pathological ring sideroblasts in the bone marrow. Causes ▾ Inherited: Mutations in genes...
Differential Diagnosis of Macrocytic Anemias

Differential Diagnosis of Macrocytic Anemias

Introduction Macrocytic anemia is a specific type of anemia that combines two conditions: macrocytosis and anemia. Macrocytosis refers to a condition where red blood cells are larger than normal. It’s itself not a disease, but rather an abnormality detected in a...