by MH Team | Dec 11, 2023 | Lab Protocols, Platelet Disorders
Introduction The activated partial thromboplastin time (APTT) is a coagulation test that measures the intrinsic pathway of blood clotting. While the APTT itself is a valuable diagnostic tool, it can be further enhanced through the use of manual mixing studies. Mixing...
by MH Team | Dec 5, 2023 | White Blood Cells
TL;DR Acute myeloid leukemia (AML) is an aggressive neoplasm of the myeloid lineage caused by acquired somatic defects due to either environmental influences e.g. chemicals, drugs, radiation or infections e.g.bacteria, protozoa in early hematopoietic blasts that...
by MH Team | Dec 1, 2023 | Lab Protocols, Transfusion Medicine
Introduction The ABO and RhD blood groups are two of the most important systems for classifying human blood. They are determined by the presence or absence of specific antigens on the surface of red blood cells. The ABO Blood Group System The ABO blood group system is...
by MH Team | Nov 29, 2023 | Red Blood Cells
TL;DR Alpha thalassemia is an inherited hemolytic anemia due deletions or point mutation (uncommon) of the α-globin gene leading to reduced production or absence of α-chains needed for hemoglobin. It has an autosomal recessive inheritance pattern. Genetics ▾...
by MH Team | Nov 28, 2023 | Lab Protocols, Red Blood Cells
Introduction HPLC, or High Performance Liquid Chromatography, is a powerful tool used to detect hemoglobinopathies. Hemoglobinopathies, a group of genetic disorders that affect the structure or production of hemoglobin, the oxygen-carrying protein in red blood cells,...
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