by MH Team | May 19, 2025 | Platelet Disorders
Key Takeaways Glanzmann thrombasthenia is a rare, inherited bleeding disorder characterized by defective or deficient platelet αIIbβ3 (GPIIb/IIIa) integrin leading impaired platelet aggregation despite normal platelet count. Pathophysiology...
by MH Team | May 16, 2025 | Platelet Disorders
Key Takeaways Bernard-Soulier syndrome is inherited bleeding disorder characterized by large platelets, thrombocytopenia and impaired platelet function. Causes ▾: Mutations in GP1BA, GP1BB, or GP9 genes resulting in defects in the glycoprotein Ib-IX-V complex...
by MH Team | May 14, 2025 | Red Blood Cells
Introduction to Hepatomegaly Hepatomegaly is the medical term for the enlargement of the liver beyond its normal size. It’s important to understand that hepatomegaly itself is not a disease but rather a clinical sign indicating an underlying pathological process...
by MH Team | May 13, 2025 | Platelet Disorders
Key Takeaways Hematoma is a localized collection of blood outside of blood vessels, distinct from a simple bruise. Causes ▾: Can be traumatic (blunt force, penetrating, surgery) or non-traumatic (spontaneous rupture, bleeding disorders, medications). Symptoms...
by MH Team | May 10, 2025 | Platelet Disorders
Key Takeaways Purpura are purple/red skin spots due to bleeding under the skin. Size distinguishes them: petechiae (<4mm), purpura (4mm-1cm), ecchymoses (>1cm/bruises). Causes ▾: Broad, often categorized by platelet count (low or normal). Low platelets...
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