Sideroblastic anemia disrupts iron use in red blood cells. Caused by genetic mutations or factors like alcohol abuse, it’s diagnosed by analyzing bone marrow for ring sideroblasts, iron-laden structures.
Red Blood Cells
Differential Diagnosis of Macrocytic Anemias
Macrocytosis, larger-than-normal red blood cells, can be a sign of vitamin B12 or folate deficiency, liver disease, or bone marrow issues. Early diagnosis is key for targeted treatment.
Differential Diagnosis of Microcytic Hypochromic Anemia
Hypochromic anemia, marked by pale, small red blood cells, has various causes beyond iron deficiency. A proper diagnosis is crucial for effective treatment. Ruling out conditions like thalassemia or lead poisoning ensures targeted therapy.
Vitamin B12 Deficiency Anemia
Vitamin B12 keeps the red cells & nerves healthy, but deficiency can lead to fatigue, numbness, and weakness. Early diagnosis is key to prevent complications.
Systemic Approach to Anemia
Systematic anemia diagnosis starts with a detailed history, exam & blood tests. Iron studies, B12/folate levels & other tests pinpoint the cause (iron deficiency, vitamin deficiency, etc.) leading to targeted treatment & improved outcomes.
Systemic Approach to Anemia
Systematic anemia diagnosis starts with a detailed history, exam & blood tests. Iron studies, B12/folate levels & other tests pinpoint the cause (iron deficiency, vitamin deficiency, etc.) leading to targeted treatment & improved outcomes.
Alpha Thalassemia
Alpha thalassemia is an inherited blood disorder that causes less alpha globin production, leading to less hemoglobin formation thus resulting in anemia.
High Performance Liquid Chromatography (HPLC) for Identification of Hemoglobin Subtypes
HPLC for hemoglobin subtype identification separates and quantifies different hemoglobin variants based on their unique chromatographic properties.
Glucose-6-Phosphate Dehydrogenase (G6PD) Fluorescent Spot Test
The G6PD fluorescent spot test is a rapid and simple screening method for G6PD deficiency that utilizes the enzyme’s ability to reduce NADP+ to NADPH.
Anemia: Types, Symptoms & Treatment
Anemia is a condition characterized by a deficiency in red blood cells or hemoglobin below the physiological need of the body.
Red Blood Cells (RBCs): An Overview
Red blood cells are biconcave disc-shaped cells that transport oxygen from the lungs to other parts of the body.
Conventional PCR Protocol for Downstream Sequencing in Beta Thalassemia Diagnosis
The beta globin gene PCR protocol for sequencing involves amplifying the beta globin gene using specific primers, followed by Sanger sequencing to determine the DNA sequence.
