Drug-induced immune hemolytic anemia (DIIHA) challenges diagnostic workup due to diverse mechanisms (hapten model most common). Consider DIIHA in hemolytic anemia with recent medication initiation & positive DAT.
Red Blood Cells
Autoimmune Hemolytic Anemia (AIHA)
AIHA: When your own immune system attacks healthy red blood cells, causing anemia. Treatment aims to suppress this immune response
Hemolytic Anemia
Hemolytic anemia occurs when red blood cells are destroyed faster than they’re produced, leading to fatigue, weakness, and shortness of breath.
Hereditary Hemochromatosis
Hereditary hemochromatosis, an inherited disorder, disrupts iron absorption leading to excessive iron buildup in organs like the liver, heart, and pancreas. Early diagnosis through blood tests is crucial to prevent potential complications like cirrhosis, heart failure, and diabetes. Treatment focuses on iron reduction through phlebotomy and may prevent severe health consequences.
Sideroblastic Anemia
Sideroblastic anemia disrupts iron use in red blood cells. Caused by genetic mutations or factors like alcohol abuse, it’s diagnosed by analyzing bone marrow for ring sideroblasts, iron-laden structures.
Pernicious Anemia
Pernicious anemia, an autoimmune condition, disrupts vitamin B12 absorption. This leads to fatigue, nerve problems, and a special type of anemia. Early diagnosis and B12 replacement therapy are key for good health.
Hereditary Spherocytosis
Hereditary spherocytosis (HS) is a blood disorder that causes red blood cells to be sphere-shaped and less flexible. This makes them more likely to break down, leading to anemia.