Pernicious anemia, an autoimmune condition, disrupts vitamin B12 absorption. This leads to fatigue, nerve problems, and a special type of anemia. Early diagnosis and B12 replacement therapy are key for good health.
Vitamin B12 Deficiency Anemia
Vitamin B12 keeps the red cells & nerves healthy, but deficiency can lead to fatigue, numbness, and weakness. Early diagnosis is key to prevent complications.
Systemic Approach to Anemia
Systematic anemia diagnosis starts with a detailed history, exam & blood tests. Iron studies, B12/folate levels & other tests pinpoint the cause (iron deficiency, vitamin deficiency, etc.) leading to targeted treatment & improved outcomes.

Thalassemia
Thalassemia is an inherited blood disorder causing reduced hemoglobin production. Symptoms include fatigue, weakness, and jaundice. Treatment involves blood transfusions, iron chelation, and bone marrow transplants.

Severe Malarial Anemia
Malaria, a mosquito-borne illness, can cause severe anemia (low red blood cells) leading to weakness & fatigue. While most malaria cases are mild, severe anemia requires prompt medical attention.

Jaundice (Hyperbilirubinemia)
Jaundice, a condition characterized by yellowing of the skin and eyes, is caused by hyperbilirubinemia, an abnormally high level of bilirubin in the blood. It can be a symptom of various liver or biliary tract diseases.
Glucose-6-Phosphate Dehydrogenase (G6PD) Fluorescent Spot Test
The G6PD fluorescent spot test is a rapid and simple screening method for G6PD deficiency that utilizes the enzyme’s ability to reduce NADP+ to NADPH.
Anemia: Types, Symptoms & Treatment
Anemia is a condition characterized by a deficiency in red blood cells or hemoglobin below the physiological need of the body.
Red Blood Cells (RBCs): An Overview
Red blood cells are biconcave disc-shaped cells that transport oxygen from the lungs to other parts of the body.
Conventional PCR Protocol for Downstream Sequencing in Beta Thalassemia Diagnosis
The beta globin gene PCR protocol for sequencing involves amplifying the beta globin gene using specific primers, followed by Sanger sequencing to determine the DNA sequence.
Aplastic Anemia (AA): A Bone Marrow Failure
Aplastic Anemia, a rare and serious bone marrow failure syndrome, causes pancytopenia, where all the blood cell lineages are suppressed.
Erythrocyte sedimentation rate (ESR)
ESR measures the sedimentation rate or the length red blood cells fall in a vertical tube over a period of time.