Macrocytosis, larger-than-normal red blood cells, can be a sign of vitamin B12 or folate deficiency, liver disease, or bone marrow issues. Early diagnosis is key for targeted treatment.
Red Blood Cells
Differential Diagnosis of Microcytic Hypochromic Anemia
Hypochromic anemia, marked by pale, small red blood cells, has various causes beyond iron deficiency. A proper diagnosis is crucial for effective treatment. Ruling out conditions like thalassemia or lead poisoning ensures targeted therapy.
Anemia of Chronic Disease (ACD)
ACD (anemia of chronic disease) occurs when inflammation disrupts iron use for red blood cells, causing anemia despite iron stores.
Interpretation of Iron Studies (Iron Profile)
Iron studies reveal iron deficiency, overload, and other conditions. Learn how MCV, ferritin, and other markers help decipher iron status and guide treatment.
Folate Deficiency
Folate deficiency, a lack of vitamin B9, can lead to fatigue, weakness, and even birth defects.
Thalassemia
Thalassemia is an inherited blood disorder causing reduced hemoglobin production. Symptoms include fatigue, weakness, and jaundice. Treatment involves blood transfusions, iron chelation, and bone marrow transplants.
Perls’ Prussian Blue Staining
Perls’ Prussian blue stain helps in identifying presence of iron stores in the bone marrow aspirate smear.
Leishman Stain
Leishman stain is used commonly for the identification of different cells present in the peripheral blood smear. It has acidic and basic properties.
Megaloblastic Anemia
Megaloblastic anemia is a type of anemia caused by a deficiency of vitamin B12 or folate.
Iron Deficiency Anemia (IDA)
Iron deficiency anemia (IDA) is a common blood disorder caused by a lack of iron. Iron is essential for the production of hemoglobin, a protein in red blood cells that carries oxygen. IDA causes symptoms such as fatigue, pale skin, and shortness of breath.
Beta Thalassemia
Beta thalassemia is a blood disorder caused by a mutation in the gene that produces beta globin, a protein that helps red blood cells carry oxygen. People with beta thalassemia may have mild to severe anemia, and may need blood transfusions and other treatments.
Hereditary Spherocytosis
Hereditary spherocytosis (HS) is a blood disorder that causes red blood cells to be sphere-shaped and less flexible. This makes them more likely to break down, leading to anemia.