Systematic anemia diagnosis starts with a detailed history, exam & blood tests. Iron studies, B12/folate levels & other tests pinpoint the cause (iron deficiency, vitamin deficiency, etc.) leading to targeted treatment & improved outcomes.
Red Blood Cells
Hereditary Hemochromatosis
Hereditary hemochromatosis, an inherited disorder, disrupts iron absorption leading to excessive iron buildup in organs like the liver, heart, and pancreas. Early diagnosis through blood tests is crucial to prevent potential complications like cirrhosis, heart failure, and diabetes. Treatment focuses on iron reduction through phlebotomy and may prevent severe health consequences.
Sideroblastic Anemia
Sideroblastic anemia disrupts iron use in red blood cells. Caused by genetic mutations or factors like alcohol abuse, it’s diagnosed by analyzing bone marrow for ring sideroblasts, iron-laden structures.
Jaundice (Hyperbilirubinemia)
Jaundice, a condition characterized by yellowing of the skin and eyes, is caused by hyperbilirubinemia, an abnormally high level of bilirubin in the blood. It can be a symptom of various liver or biliary tract diseases.
Thalassemia
Thalassemia is an inherited blood disorder causing reduced hemoglobin production. Symptoms include fatigue, weakness, and jaundice. Treatment involves blood transfusions, iron chelation, and bone marrow transplants.
Spleen
The spleen: A key organ for immunity and blood filtration. Learn about its function, location, and related health issues.
Perls’ Prussian Blue Staining
Perls’ Prussian blue stain helps in identifying presence of iron stores in the bone marrow aspirate smear.
Leishman Stain
Leishman stain is used commonly for the identification of different cells present in the peripheral blood smear. It has acidic and basic properties.
Megaloblastic Anemia
Megaloblastic anemia is a type of anemia caused by a deficiency of vitamin B12 or folate.
Iron Deficiency Anemia (IDA)
Iron deficiency anemia (IDA) is a common blood disorder caused by a lack of iron. Iron is essential for the production of hemoglobin, a protein in red blood cells that carries oxygen. IDA causes symptoms such as fatigue, pale skin, and shortness of breath.
Beta Thalassemia
Beta thalassemia is a blood disorder caused by a mutation in the gene that produces beta globin, a protein that helps red blood cells carry oxygen. People with beta thalassemia may have mild to severe anemia, and may need blood transfusions and other treatments.
Hereditary Spherocytosis
Hereditary spherocytosis (HS) is a blood disorder that causes red blood cells to be sphere-shaped and less flexible. This makes them more likely to break down, leading to anemia.