Red blood cell inclusions are hidden clues! These structures in RBCs signal underlying issues. Learn how they help diagnose anemia & other blood disorders.
Abnormal Red Blood Cell (RBC) Morphology
Red blood cell (RBC) shapes and sizes offer clues to health! Normal RBCs are round and disc-shaped, but abnormal shapes like sickle or teardrop forms can indicate underlying conditions like anemia. Let’s explore what these variations mean!
Drug-Induced Immune Hemolytic Anemia (DIIHA)
Drug-induced immune hemolytic anemia (DIIHA) challenges diagnostic workup due to diverse mechanisms (hapten model most common). Consider DIIHA in hemolytic anemia with recent medication initiation & positive DAT.

Pernicious Anemia
Pernicious anemia, an autoimmune condition, disrupts vitamin B12 absorption. This leads to fatigue, nerve problems, and a special type of anemia. Early diagnosis and B12 replacement therapy are key for good health.

Vitamin B12 Deficiency Anemia
Vitamin B12 keeps the red cells & nerves healthy, but deficiency can lead to fatigue, numbness, and weakness. Early diagnosis is key to prevent complications.

Severe Malarial Anemia
Malaria, a mosquito-borne illness, can cause severe anemia (low red blood cells) leading to weakness & fatigue. While most malaria cases are mild, severe anemia requires prompt medical attention.
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