Macrocytosis, larger-than-normal red blood cells, can be a sign of vitamin B12 or folate deficiency, liver disease, or bone marrow issues. Early diagnosis is key for targeted treatment.
Red Blood Cells
Differential Diagnosis of Microcytic Hypochromic Anemia
Hypochromic anemia, marked by pale, small red blood cells, has various causes beyond iron deficiency. A proper diagnosis is crucial for effective treatment. Ruling out conditions like thalassemia or lead poisoning ensures targeted therapy.
Anemia of Chronic Disease (ACD)
ACD (anemia of chronic disease) occurs when inflammation disrupts iron use for red blood cells, causing anemia despite iron stores.
Pernicious Anemia
Pernicious anemia, an autoimmune condition, disrupts vitamin B12 absorption. This leads to fatigue, nerve problems, and a special type of anemia. Early diagnosis and B12 replacement therapy are key for good health.
Vitamin B12 Deficiency Anemia
Vitamin B12 keeps the red cells & nerves healthy, but deficiency can lead to fatigue, numbness, and weakness. Early diagnosis is key to prevent complications.
Folate Deficiency
Folate deficiency, a lack of vitamin B9, can lead to fatigue, weakness, and even birth defects.
Erythrocyte sedimentation rate (ESR)
ESR measures the sedimentation rate or the length red blood cells fall in a vertical tube over a period of time.
Brilliant Cresyl Blue (BCB) Stain (Methylene Blue)
BCB or new methylene blue (NMB) stains are also known as supravital stains. These stains are commonly used to stain reticulocytes, Heinz bodies or H inclusions
Preparation of Peripheral Blood Smears
A drop of blood spread on a slide, reveals morphological abnormalities of the blood cells that can be viewed under the microscope.
CBC with Differential and Other Reference Ranges
Reference ranges like complete blood count (CBC) with differential are important because they provide a baseline for interpreting laboratory test results.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
G6PD deficiency is a common inherited blood disorder that can cause your red blood cells to break down when exposed to certain foods, drugs, or infections.
Sickle Cell Anemia
Sickle cell anemia is a blood disorder that causes red blood cells to be sickle-shaped and less flexible. This can lead to blockages in blood vessels, pain, and organ damage.
