Hemostasis Disorders

Hemophilia A

Hemophilia A is an X-linked bleeding disorder from a Factor VIII deficiency. It causes deep joint bleeds and is managed by FVIII replacement or gene therapy.

Factor V Leiden Thrombophilia

An inherited blood clotting disorder, Factor V Leiden increases your risk of developing dangerous clots like DVT and PE.

Coagulation Screening Panel Interpretation (Coagulation Panel)

A coagulation screening panel is a vital diagnostic tool. It assesses blood clotting (hemostasis) via PT, aPTT, & platelet count, revealing bleeding or clotting risks.

Henoch-Schönlein purpura (HSP): Palpable rash, joint & belly pain, often in kids. Usually resolves in weeks, but need to monitor kidneys.

Inside VTE: Blood flow slows, platelets clump, fibrin mesh traps cells, forming a clot. Breakaway clot can travel to lungs, leading to life-threatening pulmonary embolism (PE).

Venous Thrombosis (VTE)

Hemostasis Disorders

Venous thromboembolism: Unilaterla leg pain with lungs at risk. Master Virchow’s triad (stasis, hypercoagulability, injury), recognize DVT & PE, and advocate for early diagnosis & prevention.

Arterial Thrombosis

Hemostasis Disorders

Heart attacks, strokes, amputations: All linked to one silent threat. Explore the world of arterial thrombosis and learn how to prevent it.

Platelet aggregation curve showing two distinct phases: initial wave due to direct agonist stimulation, followed by larger wave driven by released nucleotides.

Platelet Aggregation Test (PAT)

Hemostasis Disorders, Lab Protocols

Platelet aggregation test: Checking how blood cells clump to form clots using different agonists.

The 4 key processes involved in hemostasis are vasoconstriction, primary hemostasis, secondary hemostasis and fibrinolysis.

Physiology of Hemostasis

Hemostasis Disorders

Hemostasis is the remarkable biological process that keeps our blood flowing within the confines of our vascular network.

Platelet

Hemostasis Disorders

From their role in wound healing to their potential for causing harm, platelets are a captivating paradox.

Manual APTT Mixing Study

Hemostasis Disorders, Lab Protocols

Manual APTT mixing studies involve mixing patient plasma with normal plasma or specific factor concentrates to differentiate factor deficiencies from inhibitors

Hemophilia A

Factor V Leiden Thrombophilia

Coagulation Screening Panel Interpretation (Coagulation Panel)

Heparin-Induced Thrombocytopenia

Thrombophilia

Catastrophic Antiphospholipid Syndrome

Thrombocytosis (High Platelet Count)

HELLP Syndrome

Henoch-Schönlein Purpura (HSP)

Venous Thrombosis (VTE)

Arterial Thrombosis

Platelet Aggregation Test (PAT)

Physiology of Hemostasis

Platelet

Manual APTT Mixing Study

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