Hemostasis Disorders | My Hematology

Hemostasis Disorders

Hemophilia B

Hemophilia B is a rare, inherited bleeding disorder caused by a lack of Factor IX. Modern treatments now include non-factor and gene therapies

Hemophilia A

Hemophilia A is an X-linked bleeding disorder from a Factor VIII deficiency. It causes deep joint bleeds and is managed by FVIII replacement or gene therapy.

Factor V Leiden Thrombophilia

An inherited blood clotting disorder, Factor V Leiden increases your risk of developing dangerous clots like DVT and PE.

Peripheral Artery Disease (PAD)

Hemostasis Disorders

Heparin-Induced Thrombocytopenia

Hemostasis Disorders

Thrombophilia

Hemostasis Disorders

Henoch-Schönlein Purpura (HSP)

Henoch-Schönlein Purpura (HSP)

Hemostasis Disorders, Platelet Disorders

Close-up image of a peripheral blood smear showing thrombocytosis. Numerous red blood cells are visible, along with an abnormally high number of platelets, appearing as small purple dots of various sizes and shapes, distributed throughout the smear. This increased platelet count is characteristic of thrombocytosis, a medical condition where the body produces too many platelets.

Thrombocytosis (High Platelet Count)

Hemostasis Disorders, Platelet Disorders

Ecchymoses

Ecchymoses

Hemostasis Disorders, Platelet Disorders

Ecchymoses, or bruises, are skin discolorations from blood leakage. Causes range from minor injury to underlying medical issues. Understanding them is key.

Platelets clumping in primary hemostasis, forming a sticky plug to seal a wound. Red blood cells visible.

Primary Hemostasis: The Platelet Plug

Hemostasis Disorders

A formation of an quick but unstable plug as a first response to stop bleeding. Our very own platelet patch.

Inside VTE: Blood flow slows, platelets clump, fibrin mesh traps cells, forming a clot. Breakaway clot can travel to lungs, leading to life-threatening pulmonary embolism (PE).

Venous Thrombosis (VTE)

Hemostasis Disorders

Venous thromboembolism: Unilaterla leg pain with lungs at risk. Master Virchow’s triad (stasis, hypercoagulability, injury), recognize DVT & PE, and advocate for early diagnosis & prevention.

The pathophysiology of arterial thrombosis including artherosclerosis formation, plaque rupture, clot formation and thickening of vessel wall in arterial thrombosis

Arterial Thrombosis

Hemostasis Disorders

Heart attacks, strokes, amputations: All linked to one silent threat. Explore the world of arterial thrombosis and learn how to prevent it.

Platelet aggregation curve showing two distinct phases: initial wave due to direct agonist stimulation, followed by larger wave driven by released nucleotides.

Platelet Aggregation Test (PAT)

Hemostasis Disorders, Lab Protocols

Platelet aggregation test: Checking how blood cells clump to form clots using different agonists.

The 4 key processes involved in hemostasis are vasoconstriction, primary hemostasis, secondary hemostasis and fibrinolysis.

Physiology of Hemostasis

Hemostasis Disorders

Hemostasis is the remarkable biological process that keeps our blood flowing within the confines of our vascular network.

Platelet

Platelet

Hemostasis Disorders

From their role in wound healing to their potential for causing harm, platelets are a captivating paradox.